| Entry |
|
|---|
| Name |
Metoprolol (USAN/INN) |
|---|
| Formula |
C15H25NO3
|
|---|
| Exact mass |
267.1834
|
|---|
| Mol weight |
267.3639
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01464 beta-Adrenergic receptor antagonist (Beta blocker)
DG01461 beta1-Adrenergic receptor antagonist
DG01653 Antiarrhythmics
DG01806 Class II antiarrhythmic agent
DG03231 Antihypertensive
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
|
|---|
| Remark |
| Product (DG00313): | D00601<JP/US> D00635<US> |
|
|---|
| Efficacy |
Antihypertensive, Vasodilator, beta1-Adrenergic receptor antagonist |
|---|
| Comment |
Propranolol derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04261 | Adrenergic signaling in cardiomyocytes |
|
|---|
| Metabolism |
Enzyme: CYP2D6 [HSA: 1565]
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07214 | beta-Adrenergic receptor agonists/antagonists |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C07 BETA BLOCKING AGENTS
C07A BETA BLOCKING AGENTS
C07AB Beta blocking agents, selective
C07AB02 Metoprolol
D02358 Metoprolol (USAN/INN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01464 beta-Adrenergic receptor antagonist (Beta blocker)
DG01461 beta1-Adrenergic receptor antagonist
DG00313 Metoprolol
D02358 Metoprolol
DG01653 Antiarrhythmics
DG01806 Class II antiarrhythmic agent
DG00313 Metoprolol
D02358 Metoprolol
DG03231 Antihypertensive
DG00313 Metoprolol
D02358 Metoprolol
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00313 Metoprolol
D02358 Metoprolol
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Adrenaline
ADRB1
D02358 Metoprolol (USAN/INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D02358
Drug groups [BR:br08330]
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01464 beta-Adrenergic receptor antagonist (Beta blocker)
DG01461 beta1-Adrenergic receptor antagonist
DG00313 Metoprolol
DG01653 Antiarrhythmics
DG01806 Class II antiarrhythmic agent
DG00313 Metoprolol
DG03231 Antihypertensive
DG00313 Metoprolol
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00313 Metoprolol
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 19
1 O2a O 19.1800 -14.6300
2 C1b C 20.3700 -13.9300
3 C1c C 21.5600 -14.6300
4 C1b C 22.7500 -13.9300
5 O1a O 21.5600 -16.0300
6 N1b N 24.0100 -14.6300
7 C1c C 25.2000 -13.9300
8 C1a C 26.3900 -14.6300
9 C1a C 25.2000 -12.6000
10 C8y C 19.1800 -16.0300
11 C8x C 17.9900 -16.7300
12 C8x C 17.9900 -18.1300
13 C8y C 19.1800 -18.8300
14 C8x C 20.3700 -18.1300
15 C8x C 20.3700 -16.7300
16 C1b C 19.1800 -20.2300
17 C1b C 17.9900 -20.9300
18 O2a O 16.8000 -20.2300
19 C1a C 15.6100 -20.9300
BOND 19
1 1 2 1
2 2 3 1
3 3 4 1
4 3 5 1
5 4 6 1
6 6 7 1
7 7 8 1
8 7 9 1
9 1 10 1
10 10 11 2
11 11 12 1
12 12 13 2
13 13 14 1
14 14 15 2
15 10 15 1
16 13 16 1
17 16 17 1
18 17 18 1
19 18 19 1
|
|---|
